Chemotherapy-induced genotoxic damage to bone marrow cells: long-term implications
نویسندگان
چکیده
منابع مشابه
Long-term culture of human bone marrow cells.
A method has been described for the long-term culture of human bone marrow cells in liquid medium. Hematopoiesis, as measured by the production of granulocytic-macrophage progenitor cells (CFUc), continued for at least 20 weeks and was dependent upon the presence of a marrow-derived adherent layer of cells. As in the case of murine marrow liquid cultures, the adherent layer consisted of mononuc...
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متن کاملLong-term human bone marrow cultures.
Pronlonged in vitro growth of murine bone marrow has been achieved using a flask culture system. We report the adaption of the technique to the growth of human bone marrow. In this system, CFU-GM and CFU-E are maintained for 4-9 wk. Morphologically recognizable granulopoiesis occurs for 4-6 wk and erythropoiesis for 1.5-2.5 wk. Functional T lymphocytes are maintained for at least 5 wk. The adhe...
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During deep space missions, astronauts will be exposed to low doses of charged particle irradiation. The long-term health effects of these exposures are largely unknown. We previously showed that low doses of oxygen ion (16O) irradiation induced acute damage to the hematopoietic system, including hematopoietic progenitor and stem cells in a mouse model. However, the chronic effects of low dose ...
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Objective- Adipose tissue is an appropriate source for isolation of cells with stem-cell–like properties. In the present long-term study, the effects of the omental adipose-derived nucleated cells (OADNCs) fraction were compared to those of the undifferentiated cultured bone marrow stromal cells (BMSCs) on sciatic nerve regeneration. Design- Experimental in vivo study. Animals- Fift...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 2018
ISSN: 0267-8357,1464-3804
DOI: 10.1093/mutage/gey014